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Concurrently, leptin resistance impairs macrophage polarization, blocking effective muscle building work and you may fibrosis resolution 41. These types of conclusions line up that have Navarro-Ledesma et al. 14, which recommended you to leptin opposition results in FS pathogenesis by the perpetuating pain thanks to JAK-STAT signaling. It pathway takes on a main part in the protected and you can fibrotic responses, and its own dysregulation within the FS could possibly get perform a great pathological loop from persistent pain and you can tissues firmness. Because of the broadening research help leptin’s role in the FS, coming knowledge would be to browse the if centering on leptin signaling you may serve as a restorative approach.
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